As manipulating the self-assembly of supramolecular and nanoscaleconstructs at the single-molecule level increasingly becomes the norm, new theo-retical scaffolds must be erected to replace the thermodynamic and kinetics basedmodels used to …
Aggregation of amyloid-β (Aβ) peptides is a significant event that underpins Alzheimer's disease (AD). Aβ aggregates, especially the low-molecular weight oligomers, are the primary toxic agents in AD pathogenesis. Therefore, there is increasing …
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between them is still unknown. In this …
As manipulating the self-assembly of supramolecular and nanoscale constructs at the single-molecule level increasingly becomes the norm, new theoretical scaffolds must be erected to replace the thermodynamic and kinetics based models used to describe …
Research that meaningfully integrates constraint-based modeling with machine learning is at its infancy but holds much promise. Here, we consider where machine learning has been implemented within the constraint-based modeling reconstruction …
There has been an unprecedented generation of healthcare data at clinical practices. With the availability of advanced computing frameworks and the ability to electronically mine data from disparate sources (e.g. demographics, genetics, imaging, …
Synthetic biologists endeavor to predict how the increasing complexity of multi-step signaling cascades impacts the fidelity of molecular signaling, whereby information about the cellular state is often transmitted with proteins that diffuse by a …
Self-templating propagation of protein aggregate conformations is increasingly becoming a significant factor in many neurological diseases. In Alzheimer disease (AD), intrinsically disordered amyloid-β (Aβ) peptides undergo aggregation that is …
Proteinaceous deposits composed of fibrillar amyloid-β (Aβ) are the primary neuropathological hallmarks in Alzheimer disease (AD) brains. The nucleation-dependent aggregation of Aβ is a stochastic process with frequently observed heterogeneity in …
In recent studies, miRNAs have been found to be extremely influential in many of the essential biological processes. They exhibit a self-regulatory mechanism through which they act as positive/negative regulators of expression of genes and other …